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Ed Uberbacher.
Computatational Biology Program
Oak Ridge National Laboratory and University of Tennessee-ORNL Graduate School of Genome Science and Technology, Oak Ridge, TN 37831 http://compbio.ornl.gov
The ORNL Computational Biosciences Section and collaborators have built improved systems for comprehensive, genome-wide computational annotation and computer-supported analysis of the human, mouse, and finished microbial genome data. Several improvements have been made in the automation and robustness of whole-genome human sequence data processing. These include better data management that can allow us to more efficiently process human sequences through improved analysis infrastructure, including Grail-EXP v. 4.0, Genome Analysis Pipelines, and a unique resource for high-performance biocomputing. We are using this infrastructure to analyze about 30 genomes including the current versions of the draft human genome, a number of specific human chromosomes, and chromosome-wide human-mouse comparison. In collaboration with the DOE Joint Genome Institute, we have analyzed both the draft and finished data from human chromosome 5, 16, and 19 (http://genome.ornl.gov/jgi/) and are using that experience to analyze draft data from the other human chromosomes and the recent build of the genome accomplished at UCSC. Genome-wide sequence analysis for the mouse is also proceeding in collaboration with the Jackson laboratory. We are also processing all public completed microbial genome sequences through a consistent analysis process.