Ongoing Bioinformatics Efforts in My Research Group

Ming D. Li, Ph.D.
Department of Pharmacology
University of Tennessee Health Science Center

            The first part of my talk will focus on genetic analysis at DNA level including linkage and association analysis in human populations.  Particularly, we are interesting in candidate gene-based association analysis using multiple tightly linked SNP markers in both family-based and case-control designs.  The second part of my talk will focus on cDNA microarray data analysis, which includes chip data normalization and analysis and post-chip data confirmation analysis.  If time is permitted, I will briefly describe ongoing database development related to the genomic and functional genomics efforts in our laboratory.  The final goal of these bioinformatics efforts in the laboratory is to determine what kinds of genetic factors (or genes) are responsible for nicotine dependence in human and how genes respond to nicotine administration in various rat brain regions over different time points.