The completion of the human and mouse genome sequences opens a historic era in mammalian biology. One common conclusion from these projects was the determination that mammals had only ~30,000 protein-encoding genes. Yet, despite the apparent tractability of this figure, all existing research has determined the function of only a fraction of these genes. The challenge and opportunity for genomics strategies and techniques is to accelerate the functional annotation of novel genes from the uncharted genome. Here we describe novel high-throughput technologies for gene annotation and apply them to several biological systems. (Entity-Attribute-Value with Classes and Relationships) data storage system created at the Yale Center for Medical Informatics. EAV/CR extends the EAV storage features commonly known in clinical repositories and medical trial systems to the level of creating a fluidic domain-independent application infrastructure.