Our development of a user-friendly Guide to Protein Imaging Resources begins with investigating a suite of software programs (e.g. Cn3D, RasMol, Protein Viewer) designed for the computer-assisted modeling and visualization of the 3-dimensional structures of proteins, and then developing protocols to assist novice students and faculty in using these programs. In the past several years, there has been an explosion of software modeling programs for protein structure, but a corresponding lack of suitable tutorials or guides that outline the use of these programs. Furthermore, it is often unclear what are the advantages and disadvantages of specific programs, that is, which programs are best used for teaching vs. research, and what are the utilities of various programs, in terms of their optimum applications. This guide will ultimately be developed to allow the first-time user ready access to these rather challenging programs, with the focus on those using these bioinformatics tools in the classroom. This effort will also add a new dimension to our Bioinformatic Laboratory, and will also be utilized in the EKU classroom with the development of the new undergraduate minor in Bioinformatics, an integrated experience for both Biology and Computer Science majors.