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| Abstract | ||||||||
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| New Aspects of Bioinformatics Introduced by Next-Generation Sequencing Technologies |
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| Jarret Glasscock, Ph.D. | ||||||||
| Cofactor Genomics | ||||||||
| In the last 2 years there have been significant advancements in DNA sequencing technology. This has translated into machines and protocols that produce greater than 4 orders of magnitude more data per run than the sequencing machines that were used for completing the human genome project. Data generation has increased exponentially, while the cost per base has decreased several orders of magnitude. In addition to bacterial and viral genome projects for less than $10,000, there are a significant number of new studies taking advantage of these technologies. These include polymorphism characterizations of SNPs and larger structural variation, as well as the more recent cDNA, expression, microRNA, and bisulphite studies using Next- Gen sequencing. Advances in sequencing have required parallel advances in software and visualization to handle both the magnitude and unique characteristics of this data. The computational work I will present will provide perspective on both the advantages and limitations of next-gen data and the work that is being done to overcome some of the limitations. I will also present work from recent sequencing projects to highlight bioinformatics approaches as well as to highlight differences between the observed data and the expected models. |
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| Biosketch | ||||||||
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| Jarret Glasscock, Ph.D. | ||||||||
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Jarret Glasscock received his B.S. in Molecular Biology from the University of Arizona in
1998. While at UofA he was introduced to Gene Myerʼs work (one of the authors of BLAST... and at that time the head of the CS department at UofA). After completing his degree and coursework in both the Biology and Computer Science, Jarret went on to complete a Ph.D. in molecular genetics at Washington University in St. Louis under Warren Gish, another principle author and main developer on the original BLAST paper. His thesis work focussed on supervised clustering of gene transcript data, which had a strong foundation on sequence alignment. Jarretʼs notable postdoctoral work includes leading Washington Universityʼs Computational Biology group in their genomic sequence analysis efforts. Jarret has spent the last 4 years involved in early testing and characterization of many of the Next-Gen sequencing platforms. He has recently transitioned out of his roles as Research Faculty in the Department of Genetics at Washington Universityʼs Genome Sequencing Center. Jarret is currently CTO and a founder of Cofactor Genomics, a sequencing firm focussed on bridging the gap between Next-Gen sequencing technologies (both at the bench and computer) and researchers whoʼs work would greatly benefit from such technologies. |
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